Senior Scientist

You will actively contribute to research, teaching, and administrative duties, including:

• Extensive prior experience in cellular and molecular biological characterization: Application of modern methods such as CRISPR/Cas9-mediated knockout and knock-in systems, live-cell imaging, and biosensor-based assays to investigate receptor functions.
• Research on intracellular signaling pathways, such as the analysis of second-messenger cascades, receptor trafficking, and biased signaling, preferably with a focus on chemosensory GPCR signaling pathways.
• Elucidation of cellular signaling networks: Linking molecular GPCR signaling pathways with higher-level physiological and metabolic processes, ideally with prior experience in in vivo studies.
• Structure–activity analyses: Investigating structure–activity relationships and how the chemical structure of ligands regulates receptor activation, potentially complemented by the use of in-silico methods combined with bioinformatics data analyses.
• Support for early-career researchers: Supervising and training students in chemistry, food chemistry, nutritional sciences, and related disciplines as part of Bachelor’s, Master’s, and doctoral theses.
• Supporting project proposal processes and the acquisition of third-party funding.
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• Completed doctoral degree/PhD in biochemistry, molecular biology, or a comparable field, with a focus on cellular signaling networks, preferably GPCR signal transduction.
• Solid experience in 2D and 3D cultures of immortalized and primary mammalian cells, as well as organoids, including recombinant expression systems, as a basis for functional signaling studies.
• Comprehensive knowledge of and practical experience with modern cell biology techniques, including CRISPR/Cas9-based methods, live-cell imaging, and biosensor assays (e.g., BRET/FRET).
• In-depth knowledge of GPCR signaling cascades and their molecular regulation.
• Experience with computational/in-silico methods for investigating ligand–receptor interactions, as well as script-based data analysis platforms.
• Demonstrated research competence and initiative, evidenced by international publications in peer-reviewed journals.
• Teaching skills and experience in higher education teaching, preferably in food chemistry; knowledge of e-learning is desirable.
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